Australian funnel-web spider

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Atracinae
Victorian funnelweb side.jpg
A Victorian funnel-web spider (Hadronyche modesta)
Scientific classification
Kingdom:Animalia
Phylum:Arthropoda
Class:Arachnida
Order:Araneae
Suborder:Mygalomorphae
Infraorder:Tuberculotae
Superfamily:Hexatheloidea
Family:Hexathelidae
Subfamily:Atracinae
Hogg, 1901
Genera
 
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For other uses, see Atrax (mythology).
Atracinae
Victorian funnelweb side.jpg
A Victorian funnel-web spider (Hadronyche modesta)
Scientific classification
Kingdom:Animalia
Phylum:Arthropoda
Class:Arachnida
Order:Araneae
Suborder:Mygalomorphae
Infraorder:Tuberculotae
Superfamily:Hexatheloidea
Family:Hexathelidae
Subfamily:Atracinae
Hogg, 1901
Genera
  • Atrax
    O. P.-Cambridge, 1877
  • Hadronyche
    L. Koch, 1873
  • Illawarra'
    Gray, M.R., 2010

Atracinae, commonly known as Australian funnel-web spiders, is a subfamily of spiders in the funnel-web spider family Hexathelidae.[1] Atracinae consists of three genera: Atrax, Hadronyche, and Illawarra. The subfamily includes species with medically significant venom, six species of which have severely envenomed human victims. The bite of Atrax robustus is potentially deadly, but there have been no fatalities since the introduction of modern first aid techniques and antivenom.[2] The subfamily contains 35 species. All members of the subfamily are native to Australia.[1]

Description[edit]

These spiders are medium-to-large in size, with body lengths ranging from 1 cm to 5 cm (0.4" to 2"). They are darkly coloured, ranging from black to blue-black to plum to brown, with a glossy, hairless carapace covering the front part of the body. Like the related diplurid spiders, some hexathelids have relatively long spinnerets; this is especially true of A. robustus. Males have a large mating spur projecting from the middle of their second pair of legs.[1]

Like other Mygalomorphae (also incorrectly called "Orthognatha") —an infraorder of spiders that includes the tropical tarantulas[3] —these spiders have fangs which point straight down the body and do not point towards each other (cf Araneomorphae). They have ample venom glands that lie entirely within their chelicerae. Their fangs are large and powerful, capable of penetrating fingernails and soft shoes.[4]

Funnel-webs make their burrows in moist, cool, sheltered habitats—under rocks, in and under rotting logs, some in rough-barked trees (occasionally metres above ground). They are commonly found in suburban rockeries and shrubberies, rarely in lawns or other open terrain. A funnel-web's burrow characteristically has irregular silk trip-lines radiating from the entrance.[1] Unlike some related trapdoor spiders, funnel-webs do not build lids to their burrows.

The primary range of the Australian funnel-web spiders is the eastern coast of Australia, with specimens found in New South Wales, South Australia, Victoria, and Queensland.[1][5] The only Australian states or territories without funnel-webs are Western Australia[6] and the Northern Territory.

Medical significance[edit]

Six species have severely envenomed human victims, including the C funnel web, northern tree funnel web (Hadronyche formidabilis), southern tree funnel web (H. cerberea),[7] Blue Mountains funnel web (H. versuta), Darling Downs funnel web (H. infensa) and the Port Macquarie funnel web (H. macquariensis). Australian funnel-webs are one of the most dangerous groups of spiders in the world and are regarded by some to be the most deadly, both in terms of clinical cases and venom toxicity.[8][9]

Examination of bite records has implicated wandering males in most if not all fatal funnel-web bites to humans. Adult males, recognised by the modified terminal segment of the palp, will defend themselves vigorously if they feel threatened and tend to wander during the warmer months of the year looking for receptive females for mating.[10] They are attracted to water and hence are often found in swimming pools, into which they often fall while wandering. The spiders can survive such immersion for several hours and can deliver a bite when removed from the water.[11]:p.313–22 They also show up in garages and yards in suburban Sydney. Contrary to a commonly held belief, no funnel-web spider is able to jump, although they can run quickly.[11]:p.313–22

While some very venomous spiders may give dry bites, these spiders do so much less frequently.[citation needed] An inefficient mode of delivery (to large animals) and interrupted contact are also possible causes of low volume delivery. It has been claimed that approximately 10% to 25% of bites will produce significant toxicity[8] but the likelihood cannot be predicted and all should be treated as potentially life-threatening. Funnel-webs are not normally aggressive but will defend themselves vigorously if frightened or threatened. During an attack the funnel-web spider generally maintains a tight grip on its victim and bites repeatedly, making it an especially traumatic experience for humans who are bitten and increasing the risk of severe envenomation.[12]

There have been 27 recorded deaths in Australia in the last 100 years from spider bites.[citation needed] Bites from Sydney funnel-web spiders have caused thirteen deaths (seven in children).[8] In all cases where the sex of the biting spider could be determined, it was found to be the male of the species.[13] Most victims were young, ill or infirm.[citation needed] One member of the genus Hadronyche, the northern tree funnel-web has also been claimed to cause fatal envenomation[5] but, to date, this lacks the support of a specific medical report. Assays of venom from several Hadronyche species have shown it to be similar to Atrax venom.

Toxins[edit]

There are many different toxins in the venom of Atrax and Hadronyche spiders. Collectively, these spider toxins are given the name atracotoxins (ACTX), as all these spiders belong to the subfamily Atracinae. The first toxins isolated were the δ-ACTX toxins present in the venom of both A. robustus (δ-ACTX-Ar1, formerly known as robustoxin or atracotoxin) and H. versuta (δ-ACTX-Hv1a, formerly known as versutotoxin). Both these toxins produce the same funnel-web envenoming syndrome in monkeys as that seen in humans, suggesting that they are responsible for the physiological effects seen with crude venom.[13]

Male Sydney funnel-web spider (Atrax robustus) in warning posture

These toxins are thought to operate by opening sodium channels. They are presynaptic neurotoxins that (via sodium channels) induce spontaneous, repetitive firing of action potentials in autonomic and motor neurons and inhibit neurally mediated transmitted release resulting in a surge of endogenous acetylcholine, noradrenaline and adrenaline.[14]

Although extremely toxic to primates, the venom appears to be fairly harmless to many other animals. It has been suggested that these animals may be resistant to the venom's effects due to the presence of IgG, and possibly cross-linked IgG and IgM inactivating factors in their blood plasma that bind to the toxins responsible and neutralise them.[15]

The female venom was thought to be only about a sixth as potent to humans as that of the male.[16][citation needed] The bite of a female or juvenile may still be serious; however, considerable variability occurs in venom toxicity between species, together with assumable degrees of inefficiency in the method of venom delivery.

Symptoms[edit]

Envenomation symptoms observed following bites by these spiders are very similar. The bite is initially very painful, due to the size of the fangs penetrating the skin.[7] Puncture marks and local bleeding are also usually visible. If substantial envenomation occurs, symptoms will generally occur within minutes and progress rapidly.

Early symptoms of systemic envenomation include goose bumps, sweating, tingling around the mouth and tongue, twitching (initially facial and intercostal), salivation, watery eyes, elevated heart rate and elevated blood pressure. As systemic envenomation progresses symptoms include nausea, vomiting, shortness of breath (caused by airway obstruction), agitation, confusion, writhing, grimacing, muscle spasms, pulmonary oedema (of neurogenic or hypertensive origin), metabolic acidosis and extreme hypertension. The final stages of severe envenomation include dilation of the pupils (often fixed), uncontrolled generalised muscle twitching, unconsciousness, elevated intracranial pressure and death. When death occurs it is generally as a result of progressive hypotension or possibly elevated intracranial pressure consequent on cerebral oedema.[8][12][17]

The onset of severe envenomation can be rapid. In one prospective study, the median time to onset of envenomation was 28 minutes, with only two cases having onset after 2 hours (both had pressure immobilisation bandages applied).[8] Death may occur within a period ranging from 15 minutes[13] (this occurred when a small child was bitten) to three days.

Treatment[edit]

Due to the severity of symptoms, and the speed with which they progress, in areas where these spiders are known to live all bites from large black spiders should be treated as though they were caused by a funnel-web spider. First aid treatment for a suspected funnel-web spider bite consists of immediately applying a pressure immobilisation bandage; a technique which consists of wrapping the bitten limb with a crepe bandage, as well as applying a splint to limit movement of the limb. This technique was originally developed for snakebites but has also been shown to be effective at slowing venom movement and preventing systemic envenomation in case of funnel-web spider bite; there is evidence to suggest that periods of prolonged localisation may slowly inactivate the venom.[12][18] Emergency medical treatment should be sought as soon as possible. It is important that the pressure immobilisation bandage is not removed prematurely; it should remain in place until intravenous access has been established, adequate medical monitoring is in place and a supply of antivenom is available. A patient who is not displaying any symptoms of systemic envenomation may deteriorate rapidly when the bandage is removed.

Further supportive care may be necessary, but the mainstay of treatment is antivenom. Antivenom is raised against male Atrax robustus venom but appears to be effective for all species of funnel web spiders.[19] Funnel-web antivenom has also been shown to reverse the in vitro effects of Eastern Mouse spider (Missulena bradleyi) venom.[20]

Prior to the introduction of antivenom, envenomation resulted in significant morbidity and mortality.[21] The purified rabbit IgG antivenom was developed in 1981 through a team effort led by Dr Struan Sutherland, head of immunology at the Australian Commonwealth Serum Laboratories in Melbourne.[22] Fortunately, the antivenom is fast-acting and highly and globally effective.[23] Antivenom therapy has shortened the course of envenomation: prior to antivenom availability, the average length of hospital treatment for severe bites was about 14 days. Today, antivenom-treated patients are commonly discharged from hospital within 1 to 3 days.[13] There have been no known deaths since it became available.[8]

Species[edit]

The subfamily includes the following genera and species. Including their common names and distribution.[1]

  • Atrax robustus O. P.-Cambridge, 1877 (Sydney funnel-web spider) — Sydney, Blue Mountains, Illawarra, Hunter New South Wales
  • Atrax yorkmainorum Gray, M.R., 2010 — Australian Capital Territory and Riverina
  • Atrax sutherlandi Gray, M.R., 2010 — Far south coast of New South Wales and east Gippsland, Victoria
  • Hadronyche alpina Gray, M.R., 2010 — Kosciuszko National Park, New South Wales to Brindabella Range, Australian Capital Territory
  • Hadronyche adelaidensis (Gray, 1984) (Adelaide funnel-web spider) — South Australia
  • Hadronyche annachristiae Gray, M.R., 2010 — Kerewong and Lorne State Forests, New South Wales
  • Hadronyche anzses Raven, 2000 (Northern funnel-web spider) — Queensland
  • Hadronyche cerberea L. Koch, 1873 (Tree funnel-web spider or Southern funnel-web spider) — New South Wales
  • Hadronyche emmalizae Gray, M.R., 2010 — New South Wales
  • Hadronyche eyrei (Gray, 1984) (Eyre Peninsula funnel-web spider) — South Australia
  • Hadronyche flindersi (Gray, 1984) (Flinders funnel-web spider) — South Australia
  • Hadronyche formidabilis (Rainbow, 1914) (Northern Rivers funnel-web spider or Northern Tree funnel-web spider) — Queensland, New South Wales
  • Hadronyche infensa (Hickman, 1964) (Toowoomba funnel-web spider or Fraser Island funnel-web spider) — Queensland, New South Wales
  • Hadronyche insularis (Rainbow, 1913) — Solomon Islands
  • Hadronyche jensenae Gray, M.R., 2010 — Gippsland, Victoria
  • Hadronyche kaputarensis Gray, M.R., 2010 — Endemic to Mount Kaputar
  • Hadronyche levittgreggae Gray, M.R., 2010 — Hawkesbury River region, New South Wales
  • Hadronyche lynabrae Gray, M.R., 2010 — New South Wales
  • Hadronyche macquariensis Gray, M.R., 2010 — New South Wales
  • Hadronyche marracoonda Gray, M.R., 2010 — New South Wales
  • Hadronyche mascordi Gray, M.R., 2010 — New South Wales
  • Hadronyche meridiana Hogg, 1902 — Victoria
  • Hadronyche modesta (Simon, 1891) (Victorian funnel-web spider) — Victoria
  • Hadronyche monaro Gray, M.R., 2010 — New South Wales
  • Hadronyche monteithi Gray, M.R., 2010 — Border Ranges, Killarney, Queensland
  • Hadronyche nimoola Gray, M.R., 2010 — New South Wales
  • Hadronyche orana Gray, M.R., 2010 — New South Wales
  • Hadronyche pulvinator (Hickman, 1927) (Cascade funnel-web spider) — Tasmania
  • Hadronyche raveni Gray, M.R., 2010 — Conondale Range, Queensland
  • Hadronyche tambo Gray, M.R., 2010 — Gippsland, Victoria
  • Hadronyche valida (Rainbow & Pulleine, 1918) — Queensland, New South Wales
  • Hadronyche venenata (Hickman, 1927) (Tasmanian funnel-web spider) — Tasmania
  • Hadronyche versuta (Rainbow, 1914) (Blue Mountains funnel-web spider) — New South Wales
  • Hadronyche walkeri Gray, M.R., 2010 — New South Wales
  • Illawarra wisharti Gray, M.R., 2010 — Illawarra region, New South Wales

Footnotes[edit]

  1. ^ a b c d e f Gray, Michael R. (24 November 2010). "A revision of the Australian funnel-web spiders (Hexathelidae: Atracinae)". Records of the Australian Museum 62 (3): 285–392. doi:10.3853/j.0067-1975.62.2010.1556. ISSN 0067-1975. 
  2. ^ "Funnel-web Spiders". Australian Museum. Sydney. Retrieved 24 January 2012. 
  3. ^ Mygalomorph tarantulas are a different family from the original 'tarantula', an araneomorph lycosid from Europe. —Rod and Ken Preston-Mafham. Spiders of the World. Blandford Press, 1989, England, p. 47
  4. ^ Funnel-web Fangs National Geographic. Retrieved 4 May 2014.
  5. ^ a b Fact sheet: Funnel-web spider CSIRO Note: Though formerly well resourced in entomology, CSIRO acknowledges on this site that it currently does no research into funnel-web spiders.
  6. ^ Raymond Mascord Australian Spiders in Colour Reed Press NSW, 1991, p. 14
  7. ^ a b Isbister, Geoffrey K.; Fan, Hui Wen (2011). "Spider Bite". The Lancet 378 (9808): 2039–47. doi:10.1016/S0140-6736(10)62230-1. PMID 21762981. 
  8. ^ a b c d e f Isbister G, Gray M, Balit C, Raven R, Stokes B, Porges K, Tankel A, Turner E, White J, Fisher M (2005). "Funnel-web spider bite: a systematic review of recorded clinical cases". Med J Aust 182 (8): 407–11. PMID 15850438. 
  9. ^ Vetter, Richard S.; Isbister, Geoffrey K. (2008). "Medical Aspects of Spider Bites". Annual Review of Entomology 53: 409–29. doi:10.1146/annurev.ento.53.103106.093503. PMID 17877450. 
  10. ^ Isbister G, Gray M (2004). "Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp)". Toxicon 43 (2): 133–40. doi:10.1016/j.toxicon.2003.11.009. PMID 15019472. 
  11. ^ a b Gray M. The Distribution of Funnel-Web Spiders in Australia in Toxic Plants and Animals: A Guide for Australia. Queensland Museum Press, 1987. Page 313-22
  12. ^ a b c Australian Spider and Insect Bites; University of Sydney
  13. ^ a b c d Nicholson G, Graudins A (2002). "Spiders of medical importance in the Asia-Pacific: atracotoxin, latrotoxin and related spider neurotoxins". Clin Exp Pharmacol Physiol 29 (9): 785–94. doi:10.1046/j.1440-1681.2002.03741.x. PMID 12165044. 
  14. ^ Harris J, Sutherland S, Zar M (1981). "Actions of the crude venom of the Sydney funnel-web spider. Atrax robustus on autonomic neuromuscular transmission". Br J Pharmacol 72 (2): 335–40. doi:10.1111/j.1476-5381.1981.tb09132.x. PMC 2071519. PMID 6260279. 
  15. ^ Sheumack D, Comis A, Claassens R, Mylecharane E, Spence I, Howden M (1991). "An endogenous antitoxin to the lethal venom of the funnel web spider, Atrax robustus, in rabbit sera". Comp Biochem Physiol C 99 (1–2): 157–61. doi:10.1016/0742-8413(91)90093-9. PMID 1675965. 
  16. ^ Wiener S (1959). "The Sydney funnel-web spider (Atrax robustus): II. Venom yield and other characteristics of spider in captivity". Med J Aust 46 (2): 678–82. PMID 13844638. 
  17. ^ Torda T, Loong E, Greaves I (1980). "Severe lung oedema and fatal consumption coagulopathy after funnel-web bite". Med J Aust 2 (8): 442–4. PMID 7010098. 
  18. ^ Sutherland S, Duncan A (1980). "New first-aid measures for envenomation: with special reference to bites by the Sydney funnel-web spider (Atrax robustus)". Med J Aust 1 (8): 378–9. PMID 6771503. 
  19. ^ Graudins A, Wilson D, Alewood P, Broady K, Nicholson G (2002). "Cross-reactivity of Sydney funnel-web spider antivenom: neutralization of the in vitro toxicity of other Australian funnel-web (Atrax and Hadronyche) spider venoms". Toxicon 40 (3): 259–66. doi:10.1016/S0041-0101(01)00210-0. PMID 11711122. 
  20. ^ Rash L, Birinyi-Strachan L, Nicholson G, Hodgson W (2000). "Neurotoxic activity of venom from the Australian eastern mouse spider (Missulena bradleyi) involves modulation of sodium channel gating". Br J Pharmacol 130 (8): 1817–24. doi:10.1038/sj.bjp.0703494. PMC 1572261. PMID 10952670. 
  21. ^ Isbister G, Graudins A, White J, Warrell D (2003). "Antivenom treatment in arachnidism". J Toxicol Clin Toxicol 41 (3): 291–300. doi:10.1081/CLT-120021114. PMID 12807312. 
  22. ^ Fisher M, Raftos J, McGuinness R, Dicks I, Wong J, Burgess K, Sutherland S (1981). "Funnel-web spider (Atrax robustus) antivenom. 2. Early clinical experience". Med J Aust 2 (10): 525–6. PMID 7321948. 
  23. ^ Hartman L, Sutherland S (1984). "Funnel-web spider (Atrax robustus) antivenom in the treatment of human envenomation". Med J Aust 141 (12–13): 796–9. PMID 6503783. 

External links[edit]