Withania somnifera, known commonly as ashwagandha,Indian ginseng,poison gooseberry, or winter cherry, is a plant in the Solanaceae or nightshade family. Several other species in the genus Withania are morphologically similar. It is used as an herb in Ayurvedic medicine.
Withania somnifera is prone to several pests and diseases. Leaf spot disease caused by Alternaria alternata is the most prevalent disease, which is most severe in the plains of Punjab, Haryana, and Himachal Pradesh. Biodeterioration of its pharmaceutically active components during leaf spot disease has been reported. The Choanephora cucurbitarum causes a stem and leaf rot of Withania somnifera A treehopper, feeds on the apical portions of the stem, making them rough and woody in appearance and brown in colour. The apical leaves are shed and the plant gradually dies. The carmine red spider mite (Tetranychus urticae) is the most prevalent pest of the plant in India.
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The plant's long, brown, tuberous roots are used for medicinal purposes.
In Ayurveda, the berries and leaves are applied externally to tumors, tubercular glands, carbuncles, and ulcers. The roots are used to prepare the herbal remedy ashwagandha, which has been traditionally used to treat various symptoms and conditions.
In two published clinical trials of W. somnifera, the side effects were not significantly different from those experienced by placebo-treated individuals.
Multiple studies have shown positive effects in reducing physiological and psychological stress as well as restoring and increasing energy levels. More than one study had findings showing a significant improvement in both cardiovascular and respiratory endurance.[verification needed]
^ ab"Withania somnifera (L.) Dunal". Germplasm Resources Information Network - (GRIN) [Online Database]. Beltsville, Maryland: USDA, ARS, National Genetic Resources Program. National Germplasm Resources Laboratory. Retrieved 2011-10-29.
^ ab"Withania somnifera (L.) Dunal". PROTA (Plant Resources of Tropical Africa / Ressources végétales de l’Afrique tropicale) [Online Database]. Wageningen, Netherlands: Gurib-Fakim A. and Schmelzer G. H. Retrieved 2012-08-07.
^Stearn, W. T. (1995). Botanical Latin: History, Grammar, Syntax, Terminology and Vocabulary (4th ed.). Timber Press. ISBN0-88192-321-4.
^ abcdeMirjalili, M. H.; Moyano, E.; Bonfill, M.; Cusido, R. M.; Palazón, J. (2009). "Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine". Molecules14 (7): 2373–2393. doi:10.3390/molecules14072373. PMID19633611. edit
^ abPandit, S.; Chang, K.-W.; Jeon, J.-G. (February 2013). "Effects of Withania somnifera on the growth and virulence properties of Streptococcus mutans and Streptococcus sobrinus at sub-MIC levels". Anaerobe19: 1–8. doi:10.1016/j.anaerobe.2012.10.007.
^Ven Murthy, M. R.; Ranjekar, P. K.; Ramassamy, C.; Deshpande, M. (2010). "Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: Ashwagandha". Central Nervous System Agents in Medicinal Chemistry10 (3): 238–246. doi:10.2174/1871524911006030238. PMID20528765. edit
^Ahmad, M. K.; Mahdi, A. A.; Shukla, K. K.; Islam, N.; Rajender, S.; Madhukar, D.; Shankhwar, S. N.; Ahmad, S. (2010). "Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males". Fertility and Sterility94 (3): 989–996. doi:10.1016/j.fertnstert.2009.04.046. PMID19501822. edit
^Chopra, A.; Lavin, P.; Patwardhan, B.; Chitre, D. (2004). "A 32-Week Randomized, Placebo-Controlled Clinical Evaluation of RA-11, an Ayurvedic Drug, on Osteoarthritis of the Knees". JCR: Journal of Clinical Rheumatology10 (5): 236–245. doi:10.1097/01.rhu.0000138087.47382.6d. PMID17043520.edit
^Bucci, L. R. (2000). "Selected herbals and human exercise performance". Am J Clin Nutr72 (2 Suppl): 624S–636S.