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After the success of series one of Lead Balloon, Campbell-Hughes went on to be cast in a variety of comedy shows on British television, alongside the likes of Jennifer Saunders and Alex Mcqueen, and went on to create her own one-woman show Bluebell Welch for MTV.
Campbell-Hughes has appeared in popular UK TV series such as Silent Witness, Casualty, Blackbeard: Terror at Sea and Spooks; in Channel 4's Scapegoat; in Neil Jordan's Breakfast on Pluto; and on stage in productions such as Roberto Zucco. Her performances in Lead Balloon and Jennifer Saunders vehicle The Life and Times of Vivienne Vyle have been praised by critic Sam Wollaston of The Guardian. She wrote and starred in a series of mini comedy sketches for MTV entitled Bluebell Welch. In April 2011 she appeared in series 5 of ITV's Lewis.
Campbell-Hughes had her own fashion label, started in her teens. She ran a clothing line that sold internationally under her own name and a diffusion line for high street store Topshop. She was featured on the cover of the Sunday Times' Style supplement in December 2007, and models regularly for French fashion label Devastee. She left fashion full-time in 2005 to focus fully on "her greater love" acting.
Campbell-Hughes' film work to date has been varied, including the BBC period drama Blackbeard, the Jane Campion feature film Bright Star, the psychological thriller The Other Side of Sleep which premiered ay Cannes 2011 Director's Fortnight, Lotus Eaters premiered at Tribeca Film Festival 2011, and the BBC film When Harvey Met Bob, chronicling the lead-up to Live Aid as the charity concert celebrated its 25th anniversary.
|2005||Breakfast on Pluto||Stripper|
|2006||Blackbeard: Terror at Sea||Louis Arrot|
|Silent Witness||Fenella Lee|
|2007||Tonight Is Cancelled||Nesmir|
|The Life and Times of Vivienne Vyle||Abigail|
|Into the Rose-Garden||Katie|
|Not Safe For Work||Claire Campbell|
|Bluebell Welch||Bluebell Welch|
|Five Day Shelter||Paula|
|When Harvey Met Bob||Marsha Hunt|
|2011||Hello Carter||Girl in Lift|
|The Other Side of Sleep||Arlene Kelly|
|First Row Orchestra|
|Kelly + Victor||Kelly|