Antiplatelet drug

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An antiplatelet drug (antiaggregant) is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation. They are effective in the arterial circulation, where anticoagulants have little effect.[citation needed]

They are widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease.

Choice of antiplatelet drug[edit]

A 2006 review [2] states: "...low-dose aspirin increases the risk of major bleeding 2-fold compared with placebo. However, the annual incidence of major bleeding due to low-dose aspirin is modest—only 1.3 patients per thousand higher than what is observed with placebo treatment. Treatment of approximately 800 patients with low-dose aspirin annually for cardiovascular prophylaxis will result in only 1 additional major bleeding episode."

Antiplatelet drugs[edit]

The class of antiplatelet drugs include:

Usage[edit]

In dental implantation procedures[edit]

Dental implant procedures can be safely performed in patients on long-term antiplatelet medication, with no interruption or alteration of their medication. Such patients do not have an increased risk of prolonged or excessive postoperative bleeding.[3]

Prevention and treatment of arterial thrombosis[edit]

Treatment of established arterial thrombosis includes the use of antiplatelet drugs and thrombolytic therapy. Antiplatelet drugs alter the platelet activation at the site of vascular damage crucial to the development of arterial thrombosis.

Thrombolytic therapy is used in myocardial infarction, cerebral infarction, and, on occasion, in massive pulmonary embolism. The main risk is bleeding. Treatment should not be given to patients having had recent bleeding, uncontrolled hypertension or a hemorrhagic stroke, or surgery or other invasive procedures within the previous 10 days.

Drug toxicity[edit]

Drug toxicity may be increased when multiple antiplatelet drugs are used. Gastrointestinal bleeding is a common adverse event seen in many patients.[4]

See also[edit]

References[edit]

  1. ^ "Antiplatelet agents" at Dorland's Medical Dictionary[dead link]
  2. ^ The American Journal of Medicine, Volume 119, Issue 8 , Pages 624-638, August 2006: Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials Retrieved 2013-02-08
  3. ^ Mihai Bogdan Bucur (Nov 2011). "Antiplatelet treatment implications in oral implantology". Rev. chir. oro-maxilo-fac. implantol. (in Romanian) 2 (3): 6–9. ISSN 2069-3850. 39. Retrieved 2012-04-15. (webpage has a translation button)
  4. ^ Shehab, Nadine; Laurence S. Sperling; Scott R. Kegler; Daniel S. Budnitz (2010-11-22). "National Estimates of Emergency Department Visits for Hemorrhage-Related Adverse Events From Clopidogrel Plus Aspirin and From Warfarin". Arch Intern Med 170 (21): 1926–1933. doi:10.1001/archinternmed.2010.407. PMID 21098354. Retrieved 2010-11-23.