Amgen

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Amgen Inc.
TypePublic
Traded asNASDAQAMGN
NASDAQ-100 Component
S&P 500 Component
SEHK4332
IndustryBiotechnology
Founded1980
HeadquartersThousand Oaks, California, U.S.
Key peopleRobert A. Bradway
(Chairman)
Robert A. Bradway
(President and CEO)
ProductsEpogen, Aranesp, Kineret, Enbrel, Neulasta, Neupogen, Nplate, Vectibix, Prolia, Xgeva and Sensipar/Mimpara.
RevenueIncrease US$ 15.582 billion (2011)[1]
Operating incomeDecrease US$ 4.312 billion (2011)[1]
Net incomeDecrease US$ 3.683 billion (2011)[1]
Total assetsIncrease US$ 48.871 billion (2011)[1]
Total equityDecrease US$ 19.029 billion (2011)[1]
Employees17,800 (December 2011)[1]
Websitewww.amgen.com
 
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Amgen Inc.
TypePublic
Traded asNASDAQAMGN
NASDAQ-100 Component
S&P 500 Component
SEHK4332
IndustryBiotechnology
Founded1980
HeadquartersThousand Oaks, California, U.S.
Key peopleRobert A. Bradway
(Chairman)
Robert A. Bradway
(President and CEO)
ProductsEpogen, Aranesp, Kineret, Enbrel, Neulasta, Neupogen, Nplate, Vectibix, Prolia, Xgeva and Sensipar/Mimpara.
RevenueIncrease US$ 15.582 billion (2011)[1]
Operating incomeDecrease US$ 4.312 billion (2011)[1]
Net incomeDecrease US$ 3.683 billion (2011)[1]
Total assetsIncrease US$ 48.871 billion (2011)[1]
Total equityDecrease US$ 19.029 billion (2011)[1]
Employees17,800 (December 2011)[1]
Websitewww.amgen.com

Amgen (Applied Molecular Genetics) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotechnology firm. In 2013, the company's largest selling product lines were Neulasta/Neupogen, two closely related drugs used to prevent infections in patients undergoing cancer chemotherapy; and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.

History[edit]

One of the many buildings at Amgen headquarters in Thousand Oaks
AMGen Corporate Logo, 1983
Amgen's corporate Gulfstream V departs Fox Field, Lancaster, California

The word AMGen is a portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with its initial public offering). The company's first chief executive officer, from 1980, was George B. Rathmann, followed by Gordon M. Binder in 1988,[2] followed by Kevin W. Sharer in 2000.[3] Robert A. Bradway became Amgen’s president and chief executive officer in May 2012 following Sharer's retirement.[4]

The company has made at least five major corporate acquisitions.

In June 2013, Amgen offered to buy the shares of Onyx Pharmaceuticals for $120 per share, sending Onyx shares up by around 30% after the news was announced.[5]

Timeline[edit]

Acquisition history[edit]

Products[edit]

As of December, 2013, Amgen had twelve approved drugs or therapeutic biologicals for seventeen conditions (conditions lists are highly generalized; see each article for more detail):

Products developed and then sold off[edit]

Pipeline[edit]

As of December 2013, Amgen had 11 drugs in Phase III clinical trials.[46]

See also[edit]

References[edit]

  1. ^ a b c d e f "Amgen, Form 10-K, Annual Report, Filing Date Feb 29, 2012". secdatabase.com. Retrieved Jan 8, 2013. 
  2. ^ "Amgen, Form 10-K, Annual Report, Filing Date Mar 24, 1998". secdatabase.com. Retrieved Jan 8, 2013. 
  3. ^ "Amgen, Form 10-K405, Filing Date Mar 7, 2000". secdatabase.com. Retrieved Jan 8, 2013. 
  4. ^ "Amgen, Form 8-K, Current Report, Filing Date May 24, 2012". secdatabase.com. Retrieved Jan 8, 2013. 
  5. ^ Caroline Humer (28 June 2013). "U.S. biotech Amgen offered to buy Onyx for $120 per share: report". Reuters. 
  6. ^ "Drugs@FDA: FDA Approved Drug Products". 
  7. ^ "Drugs@FDA: FDA Approved Drug Products". 
  8. ^ Lyman GH, Kuderer NM, Djulbegovic B (April 2002). "Prophylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: a meta-analysis". Am. J. Med. 112 (5): 406–11. PMID 11904116. 
  9. ^ "Drugs@FDA: FDA Approved Drug Products". 
  10. ^ Chen YF, Jobanputra P, Barton P, et al. (November 2006). "A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness". Health Technol Assess 10 (42): iii–iv, xi–xiii, 1–229. PMID 17049139. 
  11. ^ Morgan CL, Emery P, Porter D, et al. (January 2014). "Treatment of rheumatoid arthritis with etanercept with reference to disease-modifying anti-rheumatic drugs: long-term safety and survival using prospective, observational data". Rheumatology (Oxford) 53 (1): 186–94. doi:10.1093/rheumatology/ket333. PMID 24140761. 
  12. ^ Silverman, Ed. "Amgen’s Kevin Sharer: One Of The Worst CEOs". Pharmalot. [dead link]
  13. ^ Noah, Timothy. "An Amgen Payoff?". Slate Magazine. Retrieved 3 February 2013. 
  14. ^ "Drugs@FDA: FDA Approved Drug Products". 
  15. ^ "www.accessdata.fda.gov". 
  16. ^ "FDA approves Xgeva to help prevent cancer-related bone injury". 
  17. ^ Terhune, Chad. "Amgen pleads guilty to improper marketing of anemia drug Aranesp". Los Angeles Times. Retrieved 2 February 2013. 
  18. ^ Husten, Larry. "Amgen Pleads Guilty To Misbranding Anemia Drug Aranesp". Forbes. Retrieved 2 February 2013. 
  19. ^ "Article > Amgen's Aranesp fails in heart trial, Singapore plant planned". 
  20. ^ "Amgen Inc. pleads guilty to federal charge in Brooklyn and pays $762 million to resolve criminal liability and civil fraud allegations" (Press release). Department of Justice – Office of Public Affairs. December 19, 2012. Retrieved 3 October 2013. 
  21. ^ Lipton, Eric. "Fiscal Footnote: Big Senate Gift to Drug Maker". New York Times. Retrieved 2 February 2013. 
  22. ^ "Jon Entine: New York Times Mum After Congressional Budget Office Rebukes Bungled Amgen/Medicare Investigation". 
  23. ^ "CBO analysis shows keeping oral drugs out of ESRD bundle could save money | Nephrology News & Issues". 
  24. ^ Johnson, Luke. "Russ Feingold's Progressives United Launches Petition Against Amgen's Fiscal Cliff Deal". The Huffington Post. 
  25. ^ "FDA halts Amgen drug trial after 14-year-old dies". CBS News. Retrieved 26 February 2013. 
  26. ^ [+++++http://www.fda.gov/Drugs/DrugSafety/ucm340551.htm "FDA Drug Safety Communication: Pediatric clinical studies of Sensipar (cinacalcet hydrochloride) suspended after report of death"]. 
  27. ^ "Amgen, Form 8-K/A, Filing Date Feb 2, 1995". secdatabase.com. Retrieved Jan 8, 2013. 
  28. ^ "Amgen, Form 425, Filing Date Oct 16, 2000". secdatabase.com. Retrieved Jan 8, 2013. 
  29. ^ "Amgen, Form 8-K, Current Report, Filing Date Dec 17, 2001". secdatabase.com. Retrieved Jan 8, 2013. 
  30. ^ Amgen Completes Acquisition Of IMMUNEX
  31. ^ "Amgen, Form 8-K, Current Report, Filing Date Mar 29, 2004". secdatabase.com. Retrieved Jan 8, 2013. 
  32. ^ "Amgen, Form 8-K, Current Report, Filing Date Dec 15, 2005". secdatabase.com. Retrieved Jan 8, 2013. 
  33. ^ "Amgen, Form 8-K, Current Report, Filing Date Apr 24, 2006". secdatabase.com. Retrieved Jan 8, 2013. 
  34. ^ Amgen Completes Acquisition of Abgenix; Acquisition Provides Amgen with Full Ownership of Panitumumab and Eliminates a Denosumab Royalty
  35. ^ "Amgen, Form 8-K, Current Report, Filing Date Sep 29, 2006". secdatabase.com. Retrieved Jan 8, 2013. 
  36. ^ a b "Amgen, Form 10-Q, Quarterly Report, Filing Date Aug 9, 2007". secdatabase.com. Retrieved Jan 8, 2013. 
  37. ^ "Amgen, Form 8-K, Current Report, Filing Date Jan 25, 2011". secdatabase.com. Retrieved Jan 8, 2013. 
  38. ^ "Amgen, Form 10-Q, Quarterly Report, Filing Date May 10, 2011". secdatabase.com. Retrieved Jan 8, 2013. 
  39. ^ "Amgen, Form 8-K, Current Report, Filing Date Jan 26, 2012". secdatabase.com. Retrieved Jan 8, 2013. 
  40. ^ "Amgen, Form 8-K, Current Report, Filing Date Apr 30, 2012". secdatabase.com. Retrieved Jan 8, 2013. 
  41. ^ http://www.hurriyet.com.tr/ekonomi/20415671.asp
  42. ^ "Amgen, Form 10-Q, Quarterly Report, Filing Date May 8, 2012". secdatabase.com. Retrieved Jan 8, 2013. 
  43. ^ Guha, Malini (October 8, 2013). "Amgen swallows Onyx whole". Nature Biotechnology 31: 859—860. doi:10.1038/nbt1013-859. Retrieved November 6, 2013. 
  44. ^ a b c Amgen press office. Biovitrum Closes Product Acquisition Deal with Amgen
  45. ^ Sobi's StemGen page]
  46. ^ Amgen Phase III Pipeline, accessed December 29, 2013

External links[edit]