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The American Lebanese Syrian Associated Charities (ALSAC) has been the exclusive fund-raising organization of St. Jude Children's Research Hospital since 1957.
St. Jude requires more than $1.5 million (American) in operating costs each day. Around $180,000 is covered by patient insurance, the remaining $1.34 million/day is funded by charitable contributions to ALSAC.
To cover these costs, ALSAC raised more than $500 million annually for the hospital through its more than 30,000 fund-raising activities. These include the FedEx St. Jude Classic, which is a PGA Tour event and one of the most visible fund-raising events for the hospital. Other fund-raising programs include the St. Jude Math-A-Thon, Up 'til Dawn, direct mailings, radiothons and television marketing.
St. Jude also has a merchandise catalog called the Hope Catalog. The catalog contains everything from shirts to office items, and from patient art to "Give Thanks" wristbands.
One of the hospital's most recent and successful fund-raising efforts has been the Dream Home Giveaway. The giveaway allows contest entrants to reserve tickets for $100 each to qualify to win homes valued up to $420,000. The Dream Home Giveaway, one of the largest national fund-raising programs, is conducted in cities across the United States.
In November 2004, St. Jude launched its inaugural Thanks and Giving campaign which encourages consumers to help raise funds at participating retailers by adding a donation at checkout or by purchasing specialty items to benefit St. Jude. The campaign is supported by network television spots, advertisements in major publications, interactive marketing on Yahoo! and a movie trailer that runs on 20,000 screens nationwide. Corporations such as Target, Domino's Pizza, the Williams-Sonoma family of brands, CVS/pharmacy, Kay Jewelers, K-Mart, 7-Eleven, Inc., American Airlines, American Kiosk Management, AutoZone, BJ's Wholesale, Brooks Brothers, Busch Gardens, Casual Male XL, Catherines, Club Libby Lu, The Coffee Beanery, Diane von Furstenberg, Dollar General, Easy Spirit, GNC, Gymboree, Home Shopping Network, J. P. Morgan Chase, Marshalls, The Melting Pot, Memphis Grizzlies (NBA), Nine West, Rochester, Sag Harbor, Saks Fifth Avenue, SeaWorld, St. Louis Rams (NFL), West Elm, Westfield Shoppingtowns, Yahoo! give customers a host of opportunities to support St. Jude.
St. Jude has been named one of two International Philanthropic Projects of Epsilon Sigma Alpha International, a women's service sorority. As of July 2006, ESA has raised more than $100 million for St. Jude.
For the past five years, 83.7% of every dollar received by St. Jude has gone to the current or future needs of St. Jude. As of 2006[update], for the past two years 47% of program expenses have gone to patient care and 41% to research.
In 1999 Delta Delta Delta Fraternity, ΔΔΔ, formed a partnership with St. Jude Children's Research Hospital. St. Jude (through the fundraising branch, ALSAC) assists Tri Delta chapters in planning philanthropy events that benefit the children and subsidize research costs at St. Jude. Many chapters coordinate fundraising activities such as pancake breakfasts and football tailgates on their campuses each year. In 2002, Tri Deltas committed to raising $1 million to build a Teen Room at the St. Jude Hospital in Memphis, Tennessee. Tri Delta fulfilled the commitment in 2005. In July 2006, Tri Delta committed to raise $10 million in 10 years to build a new patient treatment floor focusing on brain tumor research at St. Jude. Tri Delta instead raised $10.4 million dollars in 4 years, which caused the title to be changed to $10 million by 10. Tri Delta's new philanthropic goal is to raise $15 million for St. Jude in 5 years, by 2015.