Pharyngitis is the / / inflammation of the pharynx, a region in the back of the throat. In most cases it is quite painful, and it is the most common cause of a [1 ] sore throat. [2 ]
Like many types of inflammation, pharyngitis can be
chronic or acute (quickly developing and temporary). Pharyngitis can result in very large tonsils, which cause trouble swallowing and breathing. Pharyngitis can be accompanied by a cough or fever, especially if caused by a systemic infection.
Most acute cases are caused by
viral infections (40–80%), with the remainder caused by bacterial infections, fungal infections, or irritants such as pollutants or chemical substances. [2 ] Treatment of viral causes is mainly [3 ] symptomatic, but bacterial or fungal causes may be treated with antibiotics and anti-fungal medicines respectively.
The word comes from the
Greek word pharanx meaning " throat" and the suffix -itis meaning "inflammation." Classification [edit ]
Pharyngitis is a type of inflammation, most commonly caused by an
upper respiratory tract infection. It may be classified as acute or chronic. An acute pharyngitis may be catarrhal, purulent or ulcerative, depending on the virulence of the causative agent and the immune capacity of the affected individual. Chronic pharyngitis is the most common otolaringologic disease and may be catarrhal, hypertrophic or atrophic.
If the inflammation includes
tonsillitis, it is called pharyngotonsillitis. Another sub classification is [4 ] nasopharyngitis (the common cold). [5 ] Cause [edit ]
The majority of cases are due to an infectious organism acquired from close contact with an infected individual.
Infectious [edit ] Viral
These comprise about 40–80% of all infectious cases and can be a feature of many different types of viral infections.
[2 ] [3 ] Bacterial
A number of different bacteria can infect the human throat. The most common is
Group A streptococcus, but others include , Streptococcus pneumoniae , Haemophilus influenzae , Bordetella pertussis , Bacillus anthracis , Corynebacterium diphtheriae , Neisseria gonorrhoeae , and Chlamydophila pneumoniae . Mycoplasma pneumoniae [6 ] Streptococcal pharyngitis Streptococcal pharyngitis or strep throat is caused by group A beta-hemolytic streptococcus (GAS). It is the most common bacterial cause of cases of pharyngitis (15–30%). [7 ] Common symptoms include [6 ] fever, sore throat, and large lymph nodes. It is a contagious infection, spread by close contact with an infected individual. A definitive diagnosis is made based on the results of a throat culture. Antibiotics are useful to both prevent complications and speed recovery. [8 ] Fusobacterium necrophorum are normal inhabitants of the oropharyngeal flora. Occasionally however it can create a Fusobacterium necrophorum peritonsillar abscess. In 1 out of 400 untreated cases Lemierre's syndrome occurs. [9 ] Diphtheria Diphtheria is a potentially life-threatening upper respiratory infection caused by which has been largely eradicated in developed nations since the introduction of childhood Corynebacterium diphtheriae vaccination programs, but is still reported in the Third World and increasingly in some areas in Eastern Europe. Antibiotics are effective in the early stages, but recovery is generally slow. Others
A few other causes are rare, but possibly fatal, and include parapharyngeal space infections:
peritonsillar abscess ("quinsy"), submandibular space infection (Ludwig's angina), and epiglottitis. [10 ] [11 ] [12 ] Fungal
Some cases of pharyngitis are caused by
fungal infection such as Candida albicans causing oral thrush. Non-infectious [edit ]
Pharyngitis may also be caused by mechanical, chemical or thermal irritation, for example cold air or
acid reflux. Some medications may produce pharyngitis such as pramipexole and antipsychotics. [13 ] [14 ] Diagnostic approach [edit ]
Modified Centor score Points Probability of Strep Management 1 or less <10% No antibiotic or culture needed 2 11–17% Antibiotic based on culture or RADT 3 28–35% 4 or 5 52% Empiric antibiotics
It is hard to differentiate a viral and a bacterial cause of a sore throat based on symptoms alone.
Thus often a throat swab is done to rule out a bacterial cause. [15 ] [16 ]
Centor criteria may be used to determine the management of people with pharyngitis. Based on 5 clinical criteria, it indicates the probability of a streptococcal infection. [8 ]
One point is given for each of the criteria:
[8 ] Absence of a cough Swollen and tender cervical lymph nodes Temperature >38.0 °C (100.4 °F) Tonsillar exudate or swelling Age less than 15 (a point is subtracted if age >44)
The McIsaac criteria adds to the Centor:
[17 ] Age less than 15: add one point Age greater than 45: subtract one point
Infectious Disease Society of America however recommends against empirical treatment and considers antibiotics only appropriate following positive testing. Testing is not needed in children under three as both group A strep and [15 ] rheumatic fever are rare, except if they have a sibling with the disease. [15 ] Management [edit ]
The majority of time treatment is symptomatic. Specific treatments are effective for bacterial, fungal, and herpes simplex infections.
Medications [edit ] Alternative [edit ] Alternative medicines are promoted and used for the treatment of sore throats. However, they are poorly supported by evidence. [23 ] [23 ] Epidemiology [edit ]
Acute pharyngitis is the most common cause of a
sore throat and, together with cough, it is diagnosed in more than 1.9 million people a year in the United States. [2 ] References [edit ] ^ "Pharyngitis". ClinicalKey. ^ a b c d Marx, John (2010). Rosen's emergency medicine: concepts and clinical practice (7th ed.). Philadelphia, Pennsylvania: Mosby/Elsevier. Chapter 30. ISBN 978-0-323-05472-0. ^ a b Acerra JR. "Pharyngitis". eMedicine . Retrieved 28 April 2010. ^ Rafei K, Lichenstein R (2006). "Airway Infectious Disease Emergencies". Pediatric Clinics of North America 53 (2): 215–242. doi: 10.1016/j.pcl.2005.10.001. PMID 16574523. ^ "www.nlm.nih.gov". ^ a b Bisno AL (January 2001). "Acute pharyngitis". N Engl J Med 344 (3): 205–11. doi: 10.1056/NEJM200101183440308. PMID 11172144. ^ Baltimore RS (February 2010). "Re-evaluation of antibiotic treatment of streptococcal pharyngitis". Curr. Opin. Pediatr. 22 (1): 77–82. doi: 10.1097/MOP.0b013e32833502e7. PMID 19996970. ^ a b c Choby BA (March 2009). "Diagnosis and treatment of streptococcal pharyngitis". Am Fam Physician 79 (5): 383–90. PMID 19275067. ^ Centor RM (2009-12-01). "Expand the pharyngitis paradigm for adolescents and young adults". Ann Intern Med 151 (11): 812–5. doi: 10.1059/0003-4819-151-11-200912010-00011. PMID 19949147. ^ "UpToDate Inc.". (registration required) ^ Reynolds SC, Chow AW (Sep–Oct 2009). "Severe soft tissue infections of the head and neck: a primer for critical care physicians". Lung 187 (5): 271–9. doi: 10.1007/s00408-009-9153-7. PMID 19653038. ^ Bansal A, Miskoff J, Lis RJ (January 2003). "Otolaryngologic critical care". Crit Care Clin 19 (1): 55–72. doi: 10.1016/S0749-0704(02)00062-3. PMID 12688577. ^ "Mirapex product insert" (PDF). Boehringer Ingelheim. 2009 . Retrieved 2010-06-30. ^ "Mosby's Medical Dictionary, 8th edition". Elsevier. 2009 . Retrieved 2010-06-30. ^ a b c Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, Martin JM, Van Beneden C (Sep 9, 2012). "Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America.". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 55 (10): e86–102. doi: 10.1093/cid/cis629. PMID 22965026. ^ Del Mar C (1992). "Managing sore throat: a literature review. I. Making the diagnosis". Med J Aust 156 (8): 572–5. PMID 1565052. ^ Fine AM, Nizet V, Mandl KD (2012). "Large-Scale Validation of the Centor and McIsaac Scores to Predict Group A Streptococcal Pharyngitis.". Arch Intern Med. doi: 10.1001/archinternmed.2012.950. PMID 22566485. ^ Re-evaluation of antibiotic treatment of streptococcal pharyngitis" (Curr. Opin. Pediatr. 22 (1)). February 2010. pp. 77–82. doi: 10.1097/MOP.0b013e32833502e7. PMID 19996970. ^ Hayward G, Thompson M, Heneghan C, Perera R, Del Mar C, Glasziou P (2009). "Corticosteroids for pain relief in sore throat: systematic review and meta-analysis". BMJ 339: b2976. doi: 10.1136/bmj.b2976. PMC 2722696. PMID 19661138. ^ "Do steroids reduce symptoms in acute pharyngitis?". BestBets.org . Retrieved 2009-01-14. ^ "LIDOCAINE VISCOUS (Xylocaine Viscous) side effects, medical uses, and drug interactions.". ^ Del Mar CB, Glasziou PP, Spinks AB (2004). "Antibiotics for sore throat". In Del Mar, Chris. (2): CD000023. Cochrane Database Syst Rev doi: 10.1002/14651858.CD000023.pub2. PMID 15106140. - Meta-analysis of published research ^ a b "Sore throat: Self-care". Mayo Clinic . Retrieved 2007-09-17.