AST/ALT ratio

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AST/ALT ratio
Diagnostics
LOINC16325-3, 1916-6
 
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AST/ALT ratio
Diagnostics
LOINC16325-3, 1916-6

The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio is sometimes useful in differentiating between causes of liver damage (hepatotoxicity).[1][2][3]

Interpretation[edit]

However, the AST/ALT ratio is less useful in scenarios where the liver enzymes are not elevated, or where multiple conditions co-exist.

History[edit]

Pathophysiology sample values
BMP/ELECTROLYTES:
Na+ = 140Cl = 100BUN = 20/
Glu = 150
K+ = 4CO2 = 22PCr = 1.0\
ARTERIAL BLOOD GAS:
HCO3- = 24paCO2 = 40paO2 = 95pH = 7.40
ALVEOLAR GAS:
pACO2 = 36pAO2 = 105A-a g = 10
OTHER:
Ca = 9.5Mg2+ = 2.0PO4 = 1
CK = 55BE = −0.36AG = 16
SERUM OSMOLARITY/RENAL:
PMO = 300PCO = 295POG = 5BUN:Cr = 20
URINALYSIS:
UNa+ = 80UCl = 100UAG = 5FENa = 0.95
UK+ = 25USG = 1.01UCr = 60UO = 800
PROTEIN/GI/LIVER FUNCTION TESTS:
LDH = 100TP = 7.6AST = 25TBIL = 0.7
ALP = 71Alb = 4.0ALT = 40BC = 0.5
AST/ALT = 0.6BU = 0.2
AF alb = 3.0SAAG = 1.0SOG = 60
CSF:
CSF alb = 30CSF glu = 60CSF/S alb = 7.5CSF/S glu = 0.4

It is also known as the "De Ritis Ratio",[5][6] named after De Ritis, who performed early analysis on transaminases.[6]

References[edit]

  1. ^ Nyblom H, Berggren U, Balldin J, Olsson R (2004). "High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking". Alcohol Alcohol. 39 (4): 336–9. doi:10.1093/alcalc/agh074. PMID 15208167. 
  2. ^ Nyblom H, Björnsson E, Simrén M, Aldenborg F, Almer S, Olsson R (September 2006). "The AST/ALT ratio as an indicator of cirrhosis in patients with PBC". Liver Int. 26 (7): 840–5. doi:10.1111/j.1478-3231.2006.01304.x. PMID 16911467. 
  3. ^ Gopal DV, Rosen HR (February 2000). "Abnormal findings on liver function tests. Interpreting results to narrow the diagnosis and establish a prognosis". Postgrad Med 107 (2): 100–2, 105–9, 113–4. doi:10.3810/pgm.2000.02.869. PMID 10689411. 
  4. ^ Sorbi D, Boynton J, Lindor KD (April 1999). "The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease". Am. J. Gastroenterol. 94 (4): 1018–22. doi:10.1111/j.1572-0241.1999.01006.x. PMID 10201476. 
  5. ^ Kenneth D. McClatchey (2002). Clinical laboratory medicine. Lippincott Williams & Wilkins. pp. 288–. ISBN 978-0-683-30751-1. Retrieved 21 May 2010. 
  6. ^ a b De Ritis F, Coltorti M, Giusti G (July 2006). "An enzymic test for the diagnosis of viral hepatitis: the transaminase serum activities. 1957". Clin. Chim. Acta 369 (2): 148–52. doi:10.1016/j.cca.2006.05.001. PMID 16781697. 

See also[edit]