AKT3

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V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsAKT3; MPPH; PKB-GAMMA; PKBG; PRKBG; RAC-PK-gamma; RAC-gamma; STK-2
External IDsOMIM611223 MGI1345147 HomoloGene55904 ChEMBL: 4816 GeneCards: AKT3 Gene
EC number2.7.11.1
RNA expression pattern
PBB GE AKT3 219393 s at tn.png
PBB GE AKT3 212607 at tn.png
PBB GE AKT3 212609 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1000023797
EnsemblENSG00000117020ENSMUSG00000019699
UniProtQ9Y243Q9WUA6
RefSeq (mRNA)NM_001206729.1NM_011785.3
RefSeq (protein)NP_001193658.1NP_035915.3
Location (UCSC)Chr 1:
243.65 – 244.01 Mb
Chr 1:
177.02 – 177.26 Mb
PubMed search[1][2]
 
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V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsAKT3; MPPH; PKB-GAMMA; PKBG; PRKBG; RAC-PK-gamma; RAC-gamma; STK-2
External IDsOMIM611223 MGI1345147 HomoloGene55904 ChEMBL: 4816 GeneCards: AKT3 Gene
EC number2.7.11.1
RNA expression pattern
PBB GE AKT3 219393 s at tn.png
PBB GE AKT3 212607 at tn.png
PBB GE AKT3 212609 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1000023797
EnsemblENSG00000117020ENSMUSG00000019699
UniProtQ9Y243Q9WUA6
RefSeq (mRNA)NM_001206729.1NM_011785.3
RefSeq (protein)NP_001193658.1NP_035915.3
Location (UCSC)Chr 1:
243.65 – 244.01 Mb
Chr 1:
177.02 – 177.26 Mb
PubMed search[1][2]

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.[1][2]

The protein encoded by this gene is a member of the AKT serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.[3] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

Interactions

AKT3 has been shown to interact with Protein kinase Mζ.[4]

References

  1. ^ Brodbeck D, Cron P, Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain". J Biol Chem 274 (14): 9133–6. doi:10.1074/jbc.274.14.9133. PMID 10092583.
  2. ^ Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA (Jun 1999). "Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site". Biochem Biophys Res Commun 257 (3): 906–10. doi:10.1006/bbrc.1999.0559. PMID 10208883.
  3. ^ "Entrez Gene: AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10000.
  4. ^ Hodgkinson, Conrad P; Sale Elizabeth M, Sale Graham J (Aug. 2002). "Characterization of PDK2 activity against protein kinase B gamma". Biochemistry (United States) 41 (32): 10351–9. doi:10.1021/bi026065r. ISSN 0006-2960. PMID 12162751.

Further reading