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In speech, the numbers 16 and 60 are often confused. When carefully enunciated, they differ in which syllable is stressed: 16 /sɪksˈtiːn/ vs 60 /ˈsɪksti/. However, in dates such as 1666 or when contrasting numbers in the teens, such as 15, 16, 17, the stress shifts to the first syllable: 16 /ˈsɪkstiːn/.
Sixteen is the fourth power of two. For this reason, 16 was used in weighing light objects in several cultures. The British have 16 ounces in one pound; the Chinese used to have 16 liangs in one jin. In old days, weighing was done with a beam balance to make equal splits. It would be easier to split a heap of grains into sixteen equal parts through successive divisions than to split into ten parts. Chinese Taoists did finger computation on the trigrams and hexagrams by counting the finger tips and joints of the fingers with the tip of the thumb. Each hand can count up to 16 in such manner. The Chinese abacus uses two upper beads to represent the 5s and 5 lower beads to represent the 1s, the 7 beads can represent a hexadecimal digit from 0 to 15 in each column.
Sixteen is the only integer that equals mn and nm, for some unequal integers m and n (m = 4, n = 2, or vice versa). It has this property because 22 = 2 × 2. It is also equal to 32 (see tetration).
15 and 16 form a Ruth–Aaron pair under the second definition in which repeated prime factors are counted as often as they occur.
Since it is possible to find sequences of 16 consecutive integers such that each inner member shares a factor with either the first or the last member, 16 is an Erdős–Woods number. The smallest such range of 16 consecutive integers is from 2184 to 2200.
In the Netherlands, 16 is the age when all adult rights are granted, but the age of majority is 18
Minimum age at which one can buy, rent, purchase, buy tickets to, or view a 16+ rated movie in the province of Quebec. It is also the minimum age at which one can accompany a minor under 13 while buying, renting, or purchasing tickets to a 13+ rated movie in the province of Quebec
Minimum age at which one can donate blood with parental consent in many states
Minimum age at which one can obtain a 10-year passport in the United States, United Kingdom and Australia
The number of a car in the NASCAR Sprint Cup Series.run by Roush Fenway Racing and its predecessor, Roush Racing, from 1992–2000 and 2002–present. Since the car's return to the Cup Series, it has been driven by Greg Biffle.